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Surgery Day
Surgery Day
Bench-to-Bedside
Bench-to-Bedside
SIU@U
SIU@U

    Alastair D. Lamb

    Clinician Scientist & Honorary Consultant Urological Surgeon
    Barts Cancer Institute & Guys Hospital, United Kingdom

    Alastair Lamb is a Cancer Research UK funded clinician scientist & urologist based at Barts Cancer Institute and Guys Hospital in London. He runs a scientific group called SPACE (Spatial Prostate Assessment and the Circulating Environment; https://www.nds.ox.ac.uk/research/prostate-biology/areas-of-research/spatial-clonal-biolog) whose main interest is the molecular basis of localised prostate cancer. His lab interrogate spatial clonal biology to unpack prostate cancer heterogeneity, with a focus on identifying and defining clonal lethality. The longer term objective is to change the paradigm of prostate cancer screening, diagnosis and treatment. The first part of this work was published in Nature in 2022 (www.nature.com/articles/s41586-022-05023-2; youtu.be/YdzF0-PFXhc) with a follow up analysis in Molecular Cancer in 2023 (molecular-cancer.biomedcentral.com/articles/10.1186/s12943-023-01863-2).

    Alastair is also involved in clinical trials research, as co-Chief Investigator of the TRANSLATE Trial (translate.octru.ox.ac.uk/welcome-translate-trial), and a local Investigator for the ATLANTA (www.imperialprostate.org/atlanta), PROMOTE (https://www.ndorms.ox.ac.uk/octru/trials-portfolio/trials-in-set-up/promote) and FINESSE Trials (https://www.finessetrial.org/). Alongside this he set up the QUANTUM Biobank at Oxford (https://www.nds.ox.ac.uk/quantum) to facilitate tissue collections complementing research into urological malignancies.

    Clinically, he manages patients across the full spectrum of localised prostate cancer from PSA counselling, through diagnosis, surveillance and robotic prostatectomy. He introduced LATP prostate biopsy to Oxford as well as a prostatectomy planning meeting to ensure robust discussion of all cases and a consensus approach to operative steps (https://youtu.be/p_XVH7DAFD8), on the basis that intentionality and teamwork matters in complex surgery.

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